U s scientists calculated by large-scale search for new drugs against influenza

Influenza Virus is a tough target, it is steadily mutating to evade the immune system and antiviral drugs in the attack. However, recently in San Diego at the American Society of Cell Biology annual meeting, scientists announced a fight, such as Influenza A H1N1 influenza And the H5N1 type Avian flu New methods such as influenza. This method exploits the large-scale computing power to simulate a virus never before seen conformation. The use of that method, not only the University of California researchers have discovered a new molecular target for flu drugs, but also found the target only accurate attack on drugs,Adidas Soccer Shoes, these drugs have passed the United States Food And Drug Administration review. This new target is known as neuraminidase of a single large protein. This protein is present in the surface of influenza virus,Brazil soccer jerseys, one of two key proteins may allow new copy of the virus was released into their hosts. Because most popular Cold Viruses share the same subtype of neuraminidase (N1),Club america jerseys, therefore, the protein is an ideal drug target. With most of the molecular imaging or model,Soccer Training Jersey, the new method of a state of the viral protein molecule modeling, enabling scientists to better understand the behavior of proteins, and even revealed rare virus conformation. Biochemist Andrew? Mccammon and colleagues used a sophisticated computer program, the volatility of the H1N1 influenza virus neuraminidase protein of all possible conformations were simulated. Researchers in 27 neuraminidase ordered conformations and found they all have a point of integration remain the same, this point can be objective as a major inhibitor. Subsequently, the researchers have received FDA approval to conduct a review of drug libraries, molecular modeling of these drugs into small fragments, the researchers launched a large search algorithm to find those with the neuraminidase binding site has the best affinity molecules. Researchers found that 15 compounds in the fight against H1N1 influenza virus than the currently approved antiviral drugs have a higher binding affinity. For all of these 15 compounds have a single sub-structure, the researchers began the production of chemical and drug companies are looking for compounds that contain elements of these sub-structures. Currently, they have found six kinds of such compounds, and its laboratory in Australia to confront the H1N1 influenza virus testing. Known to be resistant to antiviral drugs for influenza virus variant seems to occur in a researcher discovered a completely different binding sites. This distinction is important, especially in the influenza A H1N1 influenza virus Duffy Resistance to the increasing cases of the case. If the researchers found that the six kinds of molecules in any of the proven successful, the resulting drugs will be able to provide a second line of attack to the failure to use existing antiviral drugs. University of California, San Diego Supercomputing Center of Biological Information scientist Wilfred? Lee said that the technology used in the field of drug discovery is not yet universal, because it takes a huge amount of computing time, but also quite expensive. However, the study of building a better computer infrastructure really raised the urgent need, this way we can in this way more protein research. In addition, the study can be used to develop new and more effective inhibitors. I am writer, reports some information about ,soccer shoes, .